Models are presented for the polytropic equation of state of self-gravitati
ng, quiescent interstellar gas clouds. A detailed analysis, including chemi
stry, thermal balance, and radiative transfer, is performed for the physica
l state of the gas as a function of density, metallicity, velocity held, an
d background radiation field. We find that the stiffness of the equation of
state strongly depends on all of these physical parameters, and the adiaba
tic index varies between similar to 0.2-1.4. The implications for star form
ation, in particular at high redshift and in starburst galaxies, and the in
itial stellar mass function are discussed.