Genotoxic effect of vanillin derivatives

A liquid micromodification of the DNA-repair test with the wild repair prof icient and three repair-deficient strains of Escherichia coil was used for determination of the genotoxic effect of 4-hydroxy-3-methoxybenzaldehyde (v anillin) and other phenolic compounds. The negative results obtained were c onfirmed by the assessment of the number of revertants via the Ames test. T he ability of 4-hydroxy-3-methoxybenzaldehyde (vanillin) and 2-hydroxy-3-me thoxybenzaldehyde (o-vanillin) to increase the viability of cells and to de crease the number of mutations in bacteria pre-treated with 4-nitrochinolin -1-oxide was verified.