Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMVreactivation with cidofovir

Hemorrhagic cystitis (HC) is a common complication following high-dose chem otherapy and bone marrow transplantation, and the treatment of virus-associ ated HC remains to be optimized. This is the first report on the successful use of cidofovir in a patient with HC and polyoma viruria concomitant with CMV reactivation after allogeneic BMT. Treatment led to a significant decr ease in viruria and to sustained suppression of CMV reactivation. Administe red with probenecid and hydration, cidofovir was well tolerated, and there were no side-effects.