O. Miyamoto et al., Depression of long term potentiation in gerbil hippocampus following postischemic hypothermia, BRAIN RES, 873(1), 2000, pp. 168-172
To investigate the mechanism of chronic cell death following postischemic h
ypothermia, the change of N-methyl-D-aspartate receptor (NMDAR! were examin
ed by immunohistochemistry of NMDAR1 and long-term potentiation (LTP) in th
e CA1 subfield of the gerbil hippocampus. At 1 week following postischemic
hypothermia (32 degrees Cx4 h), all CA1 neurons survived; however, immunore
activity of NMDAR1 increased in neuronal perikarya whereas decreased in den
drites in the CAL neurons. The abnormality was still observed in remaining
CA1 neurons at 1 month after hypothermia. LTP was also significantly depres
sed at 1 week after hypothermia. These results suggest that some abnormalit
ies in the glutamate receptor may be caused by ischemia; such abnormality w
ould persist in spite of hypothermia treatment, resulting in the depression
of LTP. (C) 2000 Elsevier Science B.V. All rights reserved.