Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca2+](i) and respiratory responses to hypoxia

Authors
Roy, A Rozanov, C Mokashi, A Daudu, P Al-mehdi, AB Shams, H Lahiri, S
Citation
A. Roy et al., Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca2+](i) and respiratory responses to hypoxia, BRAIN RES, 872(1-2), 2000, pp. 188-193
Citations number
20
Categorie Soggetti
Neurosciences & Behavoir
Journal title
BRAIN RESEARCH
ISSN journal
00068993 → ACNP
Volume
872
Issue
1-2
Year of publication
2000
Pages
188 - 193
Database
ISI
SICI code
0006-8993(20000728)872:1-2<188:MLIGPS>2.0.ZU;2-R
Abstract
The hypothesis that NAD(P)H oxidase may serve as an oxygen sensor was teste d using the mice deficient (knock-out) in gp91phox subunit of NAD(P)H oxida se enzyme complex and compared with wild-type (C57BL/6J) strain measuring t he ventilatory and glomus cell intracellular calcium ([Ca2+](i)) responses of carotid body to hypoxia. The hypoxic ventilatory responses as well as th e [Ca2+](i) were preserved in the NAD(P)H oxidase knock-out mice. NAD(P)H o xidase, though a major source of oxygen radical production, is not the oxyg en sensor in mice carotid body. (C) 2000 Elsevier Science B.V. All rights r eserved.