Pregnancy outcome in carriers of fragile X

Citation
J. Kallinen et al., Pregnancy outcome in carriers of fragile X, BR J OBST G, 107(8), 2000, pp. 969-972
Citations number
14
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
ISSN journal
14700328 → ACNP
Volume
107
Issue
8
Year of publication
2000
Pages
969 - 972
Database
ISI
SICI code
1470-0328(200008)107:8<969:POICOF>2.0.ZU;2-S
Abstract
Objective To evaluate pregnancy outcome in women who are carriers of fragil e X. Design Cross-sectional case-control study. Setting Department of Obstetrics and Gynaecology, Kuopio University Hospita l, Finland. Sample Sixty-three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio Universit y Hospital. Methods Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric po pulation. Results Carriers of fragile X often experienced more bleeding in late pregn ancy than did the reference group. Otherwise, the course and outcome of pre gnancy were comparable in both groups. Conclusion Pregnancy outcome in women who are carriers of fragile X is favo urable. There is no need to initiate special fetal monitoring because of th e fragile X status of the woman.