Ayw. Chang et al., Hippocampal noradrenergic neurotransmission in concurrent EEG desynchronization and inhibition of penile erection induced by cocaine in the rat, BR J PHARM, 130(7), 2000, pp. 1553-1560
1 We previously reported that cocaine may induce activation of cortical (cE
EG) and hippocampal (hEEG) electroencephalographic signals, concurrent with
inhibition of penile erection, via an action on the hippocampal formation.
The present study further evaluates the role of noradrenergic neurotransmi
ssion at the hippocampal formation in this process, using adult, male Sprag
ue-Dawley rats anaesthetized and maintained by chloral hydrate.
2 Unilateral microinjection of cocaine (100 nmoles) into the hippocampal CA
1 or CA3 subfield or dentate gyrus elicited significant activation of both
cEEG and hEEG activity. At the same time, the intracavernous pressure (ICP)
, our experimental index for penile erection, underwent a discernible reduc
tion.
3 Co-administration of equimolar doses (250 pmoles) of prazosin, naftopidil
, yohimbine or rauwolscine significantly reversed those effects elicited by
cocaine on cEEG, hEEG and ICP.
4 Microinjection unilaterally of equimolar doses (5 nmoles) of norepinephri
ne, phenylephrine or BHT 933 into the hippocampal formation, similar to coc
aine, also induced appreciable cEEG and hEEG excitation, with a simultaneou
s decrease in ICP.
5 We conclude that cocaine may activate cEEG and hEEG and decrease ICP via
noradrenergic neurotransmission, possibly engaging at least alpha(1A/D)-, a
lpha(2B)- and alpha(2C)-adrenoceptors at the hippocampal formation.