A neurobiologically informed perspective on psychotherapy

Background Polarisation of biological and psychosocial aspects of psychiatr y has promoted a form of Cartesian dualism. Current knowledge of the intera ction between biology and psychology makes it possible to consider a truly integrative approach to treatment. Aims The aim of this overview is to consider conceptual models of how psych otherapy may affect the brain. Method The literature discussing the mutual influence of genes and environ ment is surveyed. Relevant data involving the influence of psychotherapy on the brain are also reviewed. Results Research findings suggest that the brain responds to environmental influence through the alteration of gene expression; that psychotherapy has specific measurable effects on the brain; and that implicit memory may be modified by psychotherapeutic interventions. Conclusions Advances in neuroscience research have led to a more sophistica ted understanding of how psychotherapy may affect brain functioning. These developments point the way towards a new era of psychotherapy research and practice in which specific modes of psychotherapy can be designed to target specific sites of brain functioning Declaration of interest This work was funded by the Callaway Professorship of the Menninger Clinic.