The relative efficacy of two psychotherapeutic approaches to panic dis
order, namely, focused cognitive therapy (FCT) and standard cognitive
therapy (SCT) was examined. FCT focused specifically on the ''catastro
phic misinterpretation'' of physical and psychological sensations expe
rienced during panic attacks induced in the office or occurring sponta
neously between sessions. SCT focused primarily on the cognitions and
beliefs relevant to interpersonal concerns involved in generalized anx
iety. We hypothesized that FCT would he more effective than SCT since
the latter did not include an induced panic exercise (exposure conditi
on) specific to the: patient's panicogenic cognitions. Forty patients
diagnosed with panic disorder were randomly assigned to the SCT and FC
T groups for approximately 12 to 18 sessions of treatment, Both groups
reported significant decreases in the severity of the clinical measur
es at termination. Moreover, 89.5% of the SCT group and 84.2% of the F
CT group weir free of panic attacks at 1-year follow-up. Contrary to t
he predictions, the results for measures of panic attack frequency, an
xiety, and depression did not reveal any significant differences betwe
en the two groups. Results suggest that in-office ''exposure'' is nor
necessary for improvement and that a primary focus on cognitions assoc
iated with generalized anxiety may be an effective intervention. Howev
er, since improvement in panic was correlated with normalizing of pani
c-related beliefs in both conditions, it is suggested that cognitive c
hange may be a crucial ingredient of improvement in panic episodes. (C
) 1997 Elsevier Science Ltd.