Formation of 17 beta-alkoxy-16-keto steroids by reaction of 16 alpha-hydroxy-17-keto and 17 beta-hydroxy-16-keto steroids with trimethylsilyl iodide in the presence of alkyl alcohols

Authors
Nagaoka, M Endo, M Numazawa, M
Citation
M. Nagaoka et al., Formation of 17 beta-alkoxy-16-keto steroids by reaction of 16 alpha-hydroxy-17-keto and 17 beta-hydroxy-16-keto steroids with trimethylsilyl iodide in the presence of alkyl alcohols, CHEM PHARM, 48(8), 2000, pp. 1215-1218
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
8
Year of publication
2000
Pages
1215 - 1218
Database
ISI
SICI code
0009-2363(200008)48:8<1215:FO1BSB>2.0.ZU;2-Q
Abstract
16 alpha-Hydroxy-17-keto steroids, 1, 3, and 8, and their 17 beta-hydroxy-1 6-keto isomers, 4, 5, and 9, were transformed into the corresponding 17 bet a-alkoxy-16-keto derivatives on treatment with trimethylsilyl iodide (TMSI) in the presence of alkyl alcohol in CHCl3 in poor to high yields.