Preclinical trials of human erythrocyte superoxide dismutase injection

Objective To assess the quality of human erythrocyte superoxide dismutase ( SOD) injection reaching the official standard for its clinical uses. Methods Human erythrocyte SOD injection prepared by McCord-Fridovich's meth od without column chromatography but with some modifications was used in pr eclinical trials, to observe the general pharmacology and pharmacodynamics of the product. Results The quality of human erythrocyte SOD injection conformed to the off icial standard of a biological product, which was found to be non-toxic and did not have any effects on the central and autonomic nervous systems as w ell as cardiovascular and respiratory systems. The efficacy of antiinflamma tion and promotion of immune-regulation especially on carrageenan and adjuv ant-induced polyarthritis were shown in animals. Conclusion Human erythrocyte SOD injection is appropriate for prophylactic and therapeutic uses in clinical trials.