Streptococcal toxic shock-like syndrome is caused by group A streptococci a
nd characterized by multiorgan failure and soft-tissue necrosis, often in y
oung patients with a bland history and at most a minor trauma. Diagnosis is
reached through the clinical presentation, imaging methods and positive ba
cterial verification. The course is fulminant and in the case of muscle inv
olvement, mortality reaches 80-100 %. Therapy consists of immediate fasciot
omy and often of debridement of affected soft tissues with high-dose antibi
otics in intensive care. Sometimes an unconfirmed diagnosis must be suffici
ent to operate. We report the case of a 29-year-old man without an exceptio
nal history who was forced to undergo thigh amputation, multiple soft-tissu
e debridements, and after a total of 240 erythrocyte concentrates, finally
hip joint enucleation.