Gf. Ferraccioli et al., Steroid sparing therapeutic approaches to polymyalgia rheumatica-giant cell arteritis. State of the art and perspectives, CLIN EXP RH, 18(4), 2000, pp. S58-S60
The therapeutic approach to polymyalgia rheumatica (PMR) and giant cell art
eritis (GCA) remains mainly based on corticosteroids. A few studies in PMR
suggest a steroid-sparing effect with methotrexate in a subset of patients.
No real alternative to steroids exists in GCA. Given the high chance of lo
ng-term treatment with corticosteroids in both diseases, randomized control
led trials with new immunosuppressive steroid-sparing drags are eagerly awa
ited.