Evaluation of new vaccines against tuberculosis requires diagnostic tools f
or accurately identifying asymptomatic individuals infected with Mycobacter
ium tuberculosis and persons with active tuberculosis. This article discuss
es Limitations of current methods for the immunologic diagnosis of latent i
nfection and active disease and presents novel approaches to developing ski
n tests and serodiagnostic assays based on "cocktails" of multiple antigens
of M. tuberculosis.