Application of multivariate statistical process control to batch operations

This paper summarises the results of a 2-year study focusing on the develop ment of a condition monitoring system for a fed-batch fermentation system o perated by Biochemie Ltd. in Austria. Consumer pressure has resulted in a g reater emphasis in industry on product quality. As a direct consequence, th e importance of accurate process monitoring has increased steadily in recen t years. This paper demonstrates the application of multivariate statistica l routines to provide process operators with a monitoring tool capable of d etecting process abnormalities. (C) 2000 Elsevier Science Ltd. All rights r eserved.