The systematic identification of new materials for specific: engineering ap
plications with optimal values of thermophysical, mechanical and/or biologi
cal properties is a key technical challenge with obvious commercial applica
tions. The design of these new materials consists of two components: (i) th
e forward problem, which involves the prediction of how changes in the basi
c compositional units give rise to various engineering property and (ii) th
e inverse problem, which involves discovery of viable formulations that are
predicted to possess desired performance characteristics. This situation i
s however complicated by the fact that in many industrial design situations
, data are both sparse and noisy, the fundamental understanding of the syst
em is limited and time and resource constraints are stringent. Thus, a syne
rgistic approach employing first principle chemistry/physics modeling and s
tatistical techniques like Neural networks seems promising for the forward
problem. The inverse problem is addressed using ideas from evolutionary alg
orithms. Two widely different industrial product-design problems are consid
ered in this paper and the applicability of this new methodology is demonst
rated. (C) 2000 Elsevier Science Ltd. All rights reserved.