Model-based optimization and control of chromatographic processes

This contribution presents an integrated approach to the optimal operation and automatic control of chromatographic separation processes in batch elut ion mode as well as in continuous SMB operation. The new approach is based on computationally efficient simulation models and combines techniques from mathematical optimization, parameter estimation and control theory. The re sulting algorithms were implemented in an industrial standard control syste m and the capability of the proposed control approach is demonstrated on th e separation of fructose and glucose, both in batch and SMB operation mode. (C) 2000 Elsevier Science Ltd. All rights reserved.