Throughput analysis and debottlenecking of integrated batch chemical processes

In batch plants, as we attempt to increase annual throughput, we run into b ottlenecks that are either equipment or resource (e.g. utilities, labor) re lated. Throughput bottlenecks are equipment or resources that limit the amo unt of product produced per batch. Scheduling bottlenecks are units or reso urces that limit the number of batches that can be processed per year or ca mpaign. In this payer, we present a systematic simulation-based methodology for identifying bottlenecks in batch processing and a strategy for elimina ting them. The decision-making process is based on a set of operation-relat ed variables that are used to indicate the presence of bottlenecks. The imp lementation of the methodology is demonstrated with the use of a synthetic pharmaceutical example. (C) 2000 Elsevier Science Ltd. All rights reserved.