By using reactive distillation processes, limitations due to reaction equil
ibria and due to azeotropes can be overcome, resulting in an intensified ov
erall process. We here present work on the optimization of a semi-batch pro
cess, the heterogeneously catalyzed esterification of methanol and acetic a
cid. Two different cost functions, minimal batch time and maximal productiv
ity of the process are compared. Constraints are added to ensure the purity
of the product and sufficient conversion of the raw materials. The analysi
s of the influence of the prescribed conversion rates on the productivity h
elps to detect the crucial parameters of the optimization problem, giving d
eeper insight into the process. (C) 2000 Elsevier Science Ltd. All rights r
eserved.