Recent developments in process design have focused on establishing optimiza
tion-based approaches to support decision-making under uncertainty, but few
efforts have been made to study and consider how information regarding thi
s uncertainty affects optimal decisions. In this paper we develop an optima
l design framework that, besides integrating process profitability, robustn
ess and quality issues, allows one to decide how much it is worth to spend
in research and experimentation for selectively reducing parameter uncertai
nties and guiding R&D activities. The design problem is thus formulated as
a stochastic optimization problem, whose objective function includes an inf
ormation cost term, leading to the identification of optimal parameter unce
rtainty levels one should end up with, as well as the corresponding amounts
to be spent in R&D. A case study comprising a reactor and heat exchanger s
ystem is introduced and provides an illustrative application for the sugges
ted methodology. (C) 2000 Elsevier Science Ltd. All rights reserved.