Advances in mass spectrometry for proteome analysis

The most demanding problems in proteomics continue to challenge modern mass spectrometry. Recent developments in instrument design have led to lower l imits of detection, while new ion activation techniques and improved unders tanding of gas-phase ion chemistry have enhanced the capabilities of tandem mass spectrometry for peptide and protein structure elucidation. Future de velopments must address the understanding of protein-protein interactions a nd the characterisation of the dynamic proteome.