Advances in zinc finger engineering

Recently developments have been made in engineering sequence-specific zinc finger DNA-binding proteins. Advances in this area will soon make it routin e to target proteins to specific DNA sequences associated with any given ge ne. The primary interest is in the regulation of gene expression using cust omised transcription factors. However, modular catalytic domains are also b eing developed in order to engineer chimaeric proteins with customised rest riction enzyme, methylase and integrase activity.