INHIBITORY EFFECT OF ALGINIC ACIDS ON HYALURONIDASE AND ON HISTAMINE-RELEASE FROM MAST-CELLS

Authors
ASADA M SUGIE M INOUE M NAKAGOMI K HONGO S MURATA K IRIE S TAKEUCHI T TOMIZUKA N OKA S
Citation
M. Asada et al., INHIBITORY EFFECT OF ALGINIC ACIDS ON HYALURONIDASE AND ON HISTAMINE-RELEASE FROM MAST-CELLS, Bioscience, biotechnology, and biochemistry, 61(6), 1997, pp. 1030-1032
Citations number
8
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
61
Issue
6
Year of publication
1997
Pages
1030 - 1032
Database
ISI
SICI code
0916-8451(1997)61:6<1030:IEOAAO>2.0.ZU;2-W
Abstract
The effects of various types of alginic acid consisting of L-guluronic acids (G) and D-mannuronic acids (M) on hyaluronidase and mast cell d egranulation were examined. Alginic acid with an M/G ratio of 1.0 exhi bited the strongest inhibition of both activities, the higher molecula r weight alginic acids of 150 to 370 kDa being preferable in both case s, Esterification of the carboxyl residue enhanced the latter activity .