Autoerythrocyte sensitization (Gardner-Diamond) syndrome

We describe the clinical presentation and course of a patient with autoeryt hrocyte sensitization (Gardner-Diamond) syndrome, and review the literature for similar cases. A 37-yr-old female presented with recurrent episodes of painful ecchymotic bruising over the anterior aspect of both thighs. These episodes were precipitated by emotional stress. The diagnosis was confirme d by induction of similar lesions by intradermal injection of the patient's own washed red blood cells and hemoglobin. The lesions did not recur for 6 months after the cause of her emotional stress was relieved. Autoerythrocy te sensitization (Gardner-Diamond) syndrome should be considered in the dif ferential diagnosis of purpura, especially in patients with psychiatric pro blems.