Convergent synthesis of 1 alpha-hydroxyvitamin D-5

Authors
Gao, LJ Zhao, XY Vandewalle, M De Clercq, P
Citation
Lj. Gao et al., Convergent synthesis of 1 alpha-hydroxyvitamin D-5, EUR J ORG C, (15), 2000, pp. 2755-2759
Citations number
25
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
15
Year of publication
2000
Pages
2755 - 2759
Database
ISI
SICI code
1434-193X(200008):15<2755:CSO1AD>2.0.ZU;2-U
Abstract
An eleven-step. high-yielding (46%) synthesis of lu-hydroxyvitamin D-5 (2) Starting from vitamin D-2 (4) is described, in which a Julia olefination se quence is used for the construction of the (24R)-ethyl-substituted side cha in.