Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae

Authors
Garcia-Rodriguez, LJ Trilla, JA Castro, C Valdivieso, MH Duran, A Roncero, C
Citation
Lj. Garcia-rodriguez et al., Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae, FEBS LETTER, 478(1-2), 2000, pp. 84-88
Citations number
27
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
00145793 → ACNP
Volume
478
Issue
1-2
Year of publication
2000
Pages
84 - 88
Database
ISI
SICI code
0014-5793(20000728)478:1-2<84:COTCBP>2.0.ZU;2-3
Abstract
Deletion of the 1,3-beta-D-glucan synthase gene FKS1 in Saccharomyces cerev isiae induces a compensatory mechanism that is reflected in a significant i ncrease in chitin synthase III (CSIII) activity, leading to high rates of c hitin synthesis. Deregulation of CSIII activity is mainly due to the intrac ellular delocalization of Chs3p and Chs4p, the two main components of the C SIII active complex. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.