M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein

We have isolated a human cDNA encoding a novel ATP-binding cassette (ABC) p rotein whose gene was previously localized to chromosome 1q42 [Allikmets et al, (1995) Mamm. Genome 6, 111-117], The gene transcript is expressed in a ll human tissues examined, with the highest levels in bone marrow. A non-ex pressed pseudogene also exists at chromosome 15q13-14. The new protein, whi ch is most similar to the mitochondrial (M)-ABC1 protein, was also localize d to mitochondria and therefore designated 'M-ABC2'. The N-terminus of M-AB C2 was shown to contain a mitochondrial-targeting signal sequence. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Scienc e B.V. All rights reserved.