The initial pathogenesis of cadmium induced renal toxicity

The novel application of magic angle spinning H-1 NMR spectroscopy, coupled with pattern recognition techniques, has identified biochemical changes in lipid and glutamate metabolism that precede classical nephrotoxicity. Thes e changes occurred in the bank vole (Clethrionomys glareolus) after chronic dosing, at a low level of exposure and at a renal CD2+ concentration (8.4 mu g/g dry wt) that was nearly two orders of magnitude below the WHO critic al organ concentration (200 mu g/g wet wt). These early stage effects of Cd 2+ on the biochemistry of renal tissue may reflect adaptation mechanisms to the toxic insult or the preliminary stages of the toxicological cascade, ( C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.