Genotyping of Epstein-Barr virus in patients with different hematological diseases in the South of Russia.

Authors
Chikobava, MG Alkina, NV Kosukhina, NV Polischuk, VV Lebedev, VV Agrba, VZ Yakovleva, LA Spektor, MI Ushakova, ON Grigoryev, AS Lapin, BA
Citation
Mg. Chikobava et al., Genotyping of Epstein-Barr virus in patients with different hematological diseases in the South of Russia., GEMATOL TR, 45(3), 2000, pp. 19-21
Citations number
13
Categorie Soggetti
Hematology
Journal title
GEMATOLOGIYA I TRANSFUZIOLOGIYA
ISSN journal
02345730 → ACNP
Volume
45
Issue
3
Year of publication
2000
Pages
19 - 21
Database
ISI
SICI code
0234-5730(200005/06)45:3<19:GOEVIP>2.0.ZU;2-V
Abstract
Genotyping for Epstein-Barr virus (EBV) was made using polymerase chain rea ction with primers complementary to both types of EBV and primers specific to EBNA-2A (EBV-A) or EBNA-2B (EBV-B). The presence of EBV and genotyping w as studied in DNA from blood leukocytes of 18 children and 26 adult residen ts of Krasnodar Region with hematological diseases. EBV sequences were reve aled in 36 cases from 44 (81.8%). EBV-A was found in 22(50%) and EBV-B in 1 5 cases (34%). Double infection with EBV-A/EBV-B was present in 7 cases (15 %). Associations between type of EBV and certain type of hematological dise ase were not detected. Our results suggest that type-PI EBV is a prevalent sub-type in Krasnodar Region.