Relationship between E-selectin L/F554 polymorphism and blood pressure in the Stanislas cohort

We investigated the relationship between polymorphisms of the E-selectin ge ne SELE (L/F554, S/R128 and 98G/T), a cell adhesion molecule, and interindi vidual variability in blood pressure and changes over time. The study popul ation was extracted from the Stanislas cohort (1006 families), a cohort of nuclear families volunteering for a free health check-up and recruited by t he Center of Preventive Medicine in Nancy (CMP) between 1993 and 1993. For this specific study 359 men and 337 women were selected from families who h ad already visited the CMP If years before recruitment of the Stanislas Coh ort. Measurements of blood pressure 11 years before (t(-11)) and at the tim e of recruitment (t(0)), and all other measurements necessary for the analy sis (body mass index, Lipids, SELE genotypes) were available. Pregnant wome n or subjects taking antihypertensive, lipid-lowering, or anti-inflammatory medications were excluded from the study. During the follow-up period syst olic and diastolic blood pressures were lower in SELE F554 allele carriers than in those with the L/L554 genotype (p less than or equal to 0.05), but longitudinal changes were not related to any SELE polymorphism. Multiple re gression analysis showed that at t(-11) SELE L/F554 polymorphism was associ ated with both systolic and diastolic blood pressure levels (P less than or equal to 0.01 and P less than or equal to 0.05, respectively). However, th ese associations were no longer present at to. Our results suggest an age-s pecific effect of the SELE L/F554 polymorphism on blood pressure levels. If confirmed in other studies, these findings would suggest that assessment o f common variation in an adhesion molecule could be useful in predicting bl ood pressure.