K. Sasai et al., Head-and-neck stages I and II extranodal non-Hodgkin's lymphomas: Real classification and selection for treatment modality, INT J RAD O, 48(1), 2000, pp. 153-160
Citations number
22
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Purpose: We re-evaluated histopathological specimens of head and neck early
-stage extranodal non-Hodgkin's lymphoma (NHL) using the revised European a
nd American lymphoma (REAL) classification, and also investigated the relat
ionship between the clinical characteristics and histopathological classifi
cation in an attempt to evaluate the usefulness of this new classification
system in selecting treatment modalities.
Materials and Methods: Between 1979 and 1995, 117 patients with histologica
lly confirmed stages I and II NHL of head and-neck extranodal regions were
treated. Of these patients, 110 specimens were available for reevaluation.
Sixty-four patients had Stage I, and 46 had Stage II diseases. All but 3 ha
d received radiation therapy, and 59 patients were also treated with intens
ive combination chemotherapy.
Results: There were 32 extranodal marginal-zone B-cell lymphomas, 57 diffus
e large B-cell lymphomas, II peripheral T/NK-cell lymphomas, and 10 others.
The 5- and 10-year cause-specific survival rates for all patients were 72%
and 62%, respectively. Patients with extranodal marginal-zone B-cell lymph
oma or other low-grade B-cell lymphomas demonstrated higher survival rates
than patients,vith other lymphomas. Patients with peripheral T/NK lymphomas
showed the lowest survival rate.
Conclusion: The REAL classification accurately indicated the prognosis of p
atients with NHL. These results suggest that appropriate treatment modaliti
es can be selected using this classification. (C) 2000 Elsevier Science Inc
.