Extremity soft-tissue sarcomas selectively treated with surgery alone

Purpose: This study determined local control (LC), Freedom from distant rec urrence (FFDR), overall survival (OS), and potential prognostic factors in 34 adult patients with primary extremity or limb girdle soft-tissue sarcoma selectively managed with limb-conservation surgery alone. Methods and Materials: The medical records of 34 patients who underwent sur gery alone for localized soft-tissue sarcoma of the extremity were reviewed . Median duration of follow-up in survivors was 55 months (range, 24-143), There were 13 (38%) females, Eighteen (53%) of the tumors were low-grade, 1 5 (44%) were superficial, 15 (44%) were small (5 cm or less), and 16 (47%) involved the distal extremity, Results: Actuarial 5-year LC was 80%, FFDR was 86%, and OS was 82%. All rec urrences (local and distant) were in patients with high-grade tumors; their 5-year LC was 60%, FFDR was 71%, and OS was 69%. In 2 patients, metastatic disease developed either concurrent with or after their local recurrence. Univariate analysis revealed better OS, FFDR, and LC for patients with low- grade tumors (p < 0.05). Female patients had significantly better FFDR and OS (p < 0.05). Conclusion: It is appropriate to consider withholding irradiation for selec ted patients with low-grade tumors resected with negative margins if, in th e event of a local failure, a function-preserving surgical salvage is antic ipated. For patients with high-grade sarcomas, the control of local and dis tant disease was not acceptable with limb-conservation surgery alone. (C) 2 000 Elsevier Science Inc.