CATALYTIC ABILITY OF ALKALINE-PHOSPHATASE TO PROMOTE P-O-P BOND HYDROLYZES OF INORGANIC DIPHOSPHATE AND TRIPHOSPHATE

Authors
YOZA N ONOUE S KUWAHARA Y
Citation
N. Yoza et al., CATALYTIC ABILITY OF ALKALINE-PHOSPHATASE TO PROMOTE P-O-P BOND HYDROLYZES OF INORGANIC DIPHOSPHATE AND TRIPHOSPHATE, Chemistry Letters, (6), 1997, pp. 491-492
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
6
Year of publication
1997
Pages
491 - 492
Database
ISI
SICI code
0366-7022(1997):6<491:CAOATP>2.0.ZU;2-3
Abstract
Alkaline phosphatase(EC3.1.3.1) catalyzed the hydrolyses of inorganic diphosphate(pyrophosphate) and triphosphate. The rate of P-O-P bond cl eavage decreased with increasing pH at alkaline region, in contrast to the pH-dependencies of P-O-C and P-F bond cleavages. The enzyme was i nactive toward cyclic triphosphate and, unlike well-known inorganic py rophosphatase (EC3.6.1.1), was not inhibited by fluoride ion.