Headspace gas chromatographic determination of 1,3-butadiene in simulated saliva

A headspace gas chromatographic (GC) method was developed to determine 1,3- butadiene (1,3-ED) in simulated saliva in contact with chewing gum. The cal ibration graph was linear, and the limit of detection was 0.004 mg/L, which is well below the migration limit for this substance. The headspace GC met hod provides rapid and reliable analysis for monitoring 1,3-ED migration fr om chewing gum into simulated saliva. In this paper, we report headspace me thodology for sensitive determination of 1,3-ED in chewing gum and results of selected analyses, enabling preliminary assessment of possible exposure to 1,3-ED through migration.