Use of 5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid in a novel spot test to identify sialidase activity in vaginal swabs from women with bacterial vaginosis

Authors
Wiggins, R Crowley, T Horner, PJ Soothill, PW Millar, MR Corfield, AP
Citation
R. Wiggins et al., Use of 5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid in a novel spot test to identify sialidase activity in vaginal swabs from women with bacterial vaginosis, J CLIN MICR, 38(8), 2000, pp. 3096-3097
Citations number
11
Categorie Soggetti
Clinical Immunolgy & Infectious Disease",Microbiology
Journal title
JOURNAL OF CLINICAL MICROBIOLOGY
ISSN journal
00951137 → ACNP
Volume
38
Issue
8
Year of publication
2000
Pages
3096 - 3097
Database
ISI
SICI code
0095-1137(200008)38:8<3096:UO5AIA>2.0.ZU;2-7
Abstract
The validity of measuring vaginal sialidase activity to identify bacterial vaginosis (BV) was determined by using 5-bromo-4-chloro-3-indolyl-alpha-D-N -acetylneuraminic acid in a near-patient test. The sensitivity and specific ity of the test for prediction of BV were 95.6 and 96.3%, respectively. Pos itive and negative predictive values were 95.6 and 96.3%, respectively. Thi s test may be an alternative to Gram staining.