ANTIMICROBIAL EFFECTS OF THE MACROCYCLIC CU(II)-TETRAANHYDROAMINOBENZALDEHYDE COMPLEX

The Cu(II)-tetraaza macrocyclic complex exhibited antimicrobial effect s on bacteria, yeasts and filamentous fungi. The highest antibacterial activity was found with B. subtilis and S. aureus, the respective IC5 0 values being 18 and 80 mu g/L and the MIC values 50 and 1000 mu g/L. A concentration of 1 mg/L exerted a bacteriocide effect on S. aureus. The MIC value for B. subtilis was 250 times lower and for P. aerugino sa 10 times fewer than the corresponding values for ampicillin. The Cu -complex was inactive against all tested yeasts. The strongest antifun gal effect was manifested for R. nigricans, with an IC50 value under 0 .1 mg/L, whereas in A. alternata the IC50 135 mg/L.