Effectiveness and complications of vascular access closure devices after interventional procedures

Background, Vascular closure devices are designed to obtain a fast hemostas is of the vascular access site after diagnostic and interventional procedur es. This result should be obtained with a low incidence of complications. Methods. A retrospective, non-randomized study was performed to evaluate th e success rate and vascular complications associated with the use of two di fferent vascular sealing devices [Angio-Seal (Daig Corporation, Minnetonka, Minnesota) and Prostar (Perclose, Inc,, Redwood City, California)] after i nterventional procedures. Results. Eight hundred and twenty-seven devices were used (245 Angio-Seal a nd 582 Prostar). Angio-Seal success rate was 92% with a 2.5% rate of vascul ar complications; Prostar success rate was 89% with a 3.4% rate of vascular complications. Multivariate logistic regression analysis identified advanc ed age (p < 0.05) and lower weight (p < 0.05) as independent predictors of vascular complications associated with Angio-Seal use, while diabetes (p < 0.05) was found to be a predictor of vascular complications in the Prostar group. Abciximab use and larger sheath size were not associated with an inc reased probability of vascular complications. Conclusion. Angio-Seal and Prostar obtain a fast vascular access hemostasis after interventional procedures, with a low incidence of major vascular co mplications.