Enlarged cavum septi pellucidi in patients with schizophrenia: Clinical and cognitive correlates

Enlarged cavum septi pellucidi (CSP) is a neurodevelopmental anomaly that h ers been associated with schizophrenia. This study was designed to evaluate , in patients with schizophrenia, the relationship between the severity of this anomaly and measures of symptom and cognitive skills. Three groups wev e used: patients with large CSP (n = 14), patients without large CSP (n = 1 4), and healthy control subjects (n = 24). In patients with large CSP, a si gnificant, inverse relationship was found between size of CSP and measures of cognitive deficit. Thus, the greater the size of the anomaly, the greate r the cognitive deficit. No relationship was found between severity of CSP and symptom measures.