Ja. Pando et al., Synovitis occurs in some clinically normal and asymptomatic joints in patients with early arthritis, J RHEUMATOL, 27(8), 2000, pp. 1848-1854
Objective. To determine if clinically asymptomatic knee joints in patients
with recent onset arthritis reveal histological evidence of synovitis.
Methods, As part of a prospective study of patients with synovitis of less
than one year duration, we performed blind needle biopsies on the knees of
20 patients who had synovitis elsewhere but no symptoms or detectable swell
ing or tenderness of the biopsied joint.
Results, Histologic evidence of synovitis was observed in 11 knees (55%). A
ll patients with synovitis had evidence of synovial lining cell hyperplasia
, increased vascularity, and lymphocytic infiltrates. Five of 6 patients wi
th rheumatoid arthritis (RA) and 5 of 8 with undifferentiated arthritis had
histological evidence of synovitis. but none of the 5 with reactive arthri
tis (ReA) had synovitis in the asymptomatic joints. Histologic evidence of
synovitis persisted in some after clinical resolution of previous pain and
swelling, while it occurred in others with no history of previous involveme
nt of that knee.
Conclusion. Even asymptomatic joints in patients with RA and undifferentiat
ed arthritis of recent onset reveal histologic signs of synovitis. The earl
iest changes may occur before symptoms. Histologic changes also persist aft
er resolution of previous early symptoms. Evidence of inflammation was not
present in asymptomatic joints in our 5 patients diagnosed with ReA.