Large plantar wart caused by human papillomavirus-66 and resolution by topical cidofovir therapy

Warts can be difficult to diagnose and to treat in the setting of human imm unodeficiency virus (HIV) infection. A 37-year-old woman with a background of HIV presented with a large verrucous plaque involving her right foot. Hu man papillomavirus (HPV)-66 was identified in the lesional skin biopsy samp le and in scrapings obtained from her cen ix. The wart rapidly responded to topical cidofovir therapy. HPV-66 is a novel HPV type to be associated wit h verruca vulgaris. Topical cidofovir should be further investigated as an alternative treatment modality for verruca vulgaris.