Onychomadesis is defined as spontaneous separation of the nail plate from t
he nail bed, beginning at its proximal end and resulting in the shedding of
the nail. It has been associated with a variety of clinical settings, incl
uding systemic illnesses, generalized skin diseases, and drug therapies. Th
ere have been a small number of reports in the older literature of idiopath
ic onychomadesis occurring in a familial pattern. We report the case of a h
ealthy 12-year-old girl and her mother, both of whom have experienced recur
rent onychomadesis affecting multiple digits, and in the absence of any cau
sal disease or medication.