Background: Intratumoral ablative therapy is being used increasingly for th
e treatment of primary and secondary hepatic malignancies. The interstitial
point-source photon radiosurgery system (PRS) is a novel ablative techniqu
e that uses radiation therapy similar in dosimetry to interstitial brachyth
erapy.
Study Design: To determine the feasibility, toxicity, and local tissue dest
ructive capabilities of the PRS in the liver, preliminary studies in a nont
umor-bearing canine model were examined. A 6-month survival study was condu
cted. Each animal received three radiation treatments, in the right, centra
l, and left hepatic regions. Three Low-dose treatments were delivered to ea
ch of six animals (group A), generating a 2.0-cm-diameter radiated sphere w
ith a dose of 20 Gy at the lesion edge. Three high-dose treatments were del
ivered to each of six animals (group B), generating a 3.0-cm-diameter radia
ted sphere with 20 Gy at the lesion edge.
Results: The treatment reproducibly generated sharply demarcated hepatic ab
lative Lesions proportional to the administered dose. Mean lesion diameter
at 1 month was 1.6 +/- 0.2 cm in group A and 3.4 +/- 1.0 cm in group B. Les
ion size was independent of intrahepatic location, including near vascular
structures. PRS therapy, when applied to portal structures, resulted in hil
ar damage. Hilar damage appeared to be associated with arteriolar thrombosi
s and bile duct injury. Treatment of regions adjacent to large hepatic vein
s and the IVC was not associated with vessel thrombosis or stricture.
Conclusions: PRS ablation is a generally well-tolerated method that results
in consistent, well-demarcated, symmetric lesions of complete necrosis wit
h minimal adjacent parenchymal injury. Application of such an approach for
the treatment of liver tumors is promising. (J Am Coll Surg 2000;192:164-17
4. (C) 2000 by the American College of Surgeons).