Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction

Citation
Bw. Morgan et al., Ethylene glycol ingestion resulting in brainstem and midbrain dysfunction, J TOX-CLIN, 38(4), 2000, pp. 445-451
Citations number
15
Categorie Soggetti
Pharmacology,"Pharmacology & Toxicology
Journal title
JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY
ISSN journal
07313810 → ACNP
Volume
38
Issue
4
Year of publication
2000
Pages
445 - 451
Database
ISI
SICI code
0731-3810(2000)38:4<445:EGIRIB>2.0.ZU;2-L
Abstract
Introduction: Ethylene glycol toxicity has produced central nervous system abnormalities including coma, cerebral edema, and cranial nerve dysfunction . Case Report: A 26-year-old male developed widespread brainstem and midbra in dysfunction with corresponding cranial computed tomography findings afte r ingesting ethylene glycol. The computed tomography scan which was obtaine d 3 days after ethylene glycol ingestion showed low density areas in the ba sal ganglia, thalami, midbrain, and upper pons. The neurologic findings in our patient reflected dysfunction of all the areas of hypodensity on the cr anial computed tomography scan. A magnetic resonance imaging of the brain o btained 24 days after ingestion revealed bilateral putamen necrosis. The pa tient's neurologic sequelae resolved over the following 4 months.