Td. Cherkasova et Va. Yurkiv, HORMONAL-REGULATION OF CARBOHYDRATE-METABOLISM IN THE LIVER DURING INTOXICATION WITH Y-PESTIS MOUSE TOXIN, Biochemistry, 59(3), 1994, pp. 327-330
Intravenous injection to rats of ''mouse'' toxin of Yersiniapestis (fr
action II) (LD(100))) caused twofold decrease in the content of liver
glycogen and blood glucose. The B-max of beta-adrenergic receptors and
the basal and forskolin-, 5'-guanylylimidodiphosphate-, and glucagon-
stimulated adenylate cyclase activities of liver membranes were not ch
anged over the period of the intoxication. After 5 h of intoxication i
soproterenol did not activate adenylate cyclase; however, the cAMP con
tent was increased 1.5-fold compared with control. The data suggest th
at plague intoxication does not affect cAMP-dependent regulation of gl
ycogenolysis and gluconeogenesis in the liver. Also, the toxin does no
t act by decreasing alpha(1) adrenergic receptors in liver membranes b
ecause their number was actually increased by 1.3- and 1.5-fold after
1 and 2 h of intoxication, respectively, and even in the terminal stag
e it was the same as the control level.