HORMONAL-REGULATION OF CARBOHYDRATE-METABOLISM IN THE LIVER DURING INTOXICATION WITH Y-PESTIS MOUSE TOXIN

Intravenous injection to rats of ''mouse'' toxin of Yersiniapestis (fr action II) (LD(100))) caused twofold decrease in the content of liver glycogen and blood glucose. The B-max of beta-adrenergic receptors and the basal and forskolin-, 5'-guanylylimidodiphosphate-, and glucagon- stimulated adenylate cyclase activities of liver membranes were not ch anged over the period of the intoxication. After 5 h of intoxication i soproterenol did not activate adenylate cyclase; however, the cAMP con tent was increased 1.5-fold compared with control. The data suggest th at plague intoxication does not affect cAMP-dependent regulation of gl ycogenolysis and gluconeogenesis in the liver. Also, the toxin does no t act by decreasing alpha(1) adrenergic receptors in liver membranes b ecause their number was actually increased by 1.3- and 1.5-fold after 1 and 2 h of intoxication, respectively, and even in the terminal stag e it was the same as the control level.