Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma

Recent reports suggest that green tea consumption may prevent or delay the growth of human cancer, possibly by impairing tumor invasion and/or by an a nti-angiogenic effect. In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines, Namalwa, RAP1-EIO and MS-Su ltan, green tea prevented 50% of Namalwa tumors (P = 0.0017 by log-rank) an d significantly inhibited RAP1-EIO and HS-Sultan tumor growth. Notably, tre atment with the chemotherapy drug cyclophosphamide at the maximum tolerable dose was unable to prevent Namalwa tumor occurrence. In the three models e valuated, the frequency of apoptotic endothelial and tumor cells was signif icantly increased in mice given green tea compared to controls. These resul ts support further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression.