High-resolution diffusion imaging using phase-corrected segmented echo-planar imaging

Diffusion magnetic resonance imaging (MRI) was performed with a high-resolu tion segmented echo-planar imaging technique, which provided images with su bstantially less susceptibility artifacts than images obtained with single- shot echo-planar imaging (EPI). Diffusion imaging performed with any multis hot pulse sequence is inherently sensitive to motion artifacts and in order to reduce motion artifacts, the presented method utilizes navigator echo p hase corrections, performed after a one-dimensional Fourier transform along the frequency-encoding direction. Navigator echo phases were fitted to a s traight line prior to phase correction to avoid errors from internal motion . In vivo imaging was performed using electro cardiographic (ECG) triggerin g. Apparent diffusion coefficient (ADC) maps were calculated on a pixel-by- pixel basis using up to seven diffusion sensitivities, ranging from b = 0 t o 1129 x 10(6) s/m(2). (C) 2000 Elsevier Science Inc. All rights reserved.