RADIOIODINATED ESTRAMUSTINE PHOSPHATE AND ESTRAMUSTINE BINDING-PROTEIN ANTIBODY ACCUMULATE IN THE PROSTATE OF A MOUSE

BACKGROUND. The purpose of this study was to determine the distributio n of radioiodinated estramustine (RI-EMP) and a radioiodinated antibod y against estramustine binding protein (RI-EMBP-AB) in mice. METHODS. RI-EMP and RI-EMBP-AB were injected in male mice intravenously, and th e activities of tissue samples were measured 1-31 hr from the injectio n. Pure iodine-125 (RI) was used as a control. RESULTS. RI-EMP accumul ated in the prostate, which contained 2.6% of injected activity (ID) p er gram tissue at 7 hr. The liver had an activity of 21.4% ID/g at 1 h r, which decreased as RI-EMP was secreted in bile. The lung contained 2.3% ID/g at 7 hr, and it retained the activity longer than the prosta te. RI-EMBP-AB accumulated in the prostate: The activity was 2.9% ID/g at 7 hr. The gallbladder contained 6.5% ID/g at 7 hr. CONCLUSIONS. Du e to its cytotoxic and radiosensitizing properties, RI-EMP can possibl y be used for treating prostate cancer and other tumors. (C) 1997 Wile y-Liss, Inc.