Autoimmune hemolytic anemia in a patient with autosomal dominant chronic mucocutaneous candidiasis

Chronic mucocutaneous candidiasis is a heterogeneous immunodeficiency syndr ome characterized hy recurrent candidal infections of the skin, nails, and mucous membranes, The syndrome call be associated with autoimmune condition s, especially endocrine disorders. Typically, inheritance is autosomal rece ssive, and abnormal T-cell-mediated immunity is thought to be the underlyin g deficit. We describe a 27-year-old man with chronic mucocutaneous candidi asis inherited in an autosomal dominant fashion, in whom both lymphocyte bl astogenesis and delayed-type skin reactivity to Candida antigens,were norma l, Notable features of the case include autoimmune hemolytic anemia, probab le hypoparathyroidism, and hypogonadal hypogonadism.