Signaling and invasin-promoted uptake via integrin receptors

The invasin protein encoded by enteropathogenic Yersinia allows entry of ba cteria into intestinal M cells by binding to integrin receptors. In culture d cells, invasin-mediated uptake requires proteins involved in endocytosis and signaling to the cell cytoskeleton. At least four different factors hav e been demonstrated to play a role in regulating the efficiency of invasin- promoted uptake. These include receptor-ligand affinity, receptor clusterin g, signaling through focal adhesion kinase, and stimulation of cytoskeletal rearrangements by small GTP binding proteins. (C) 2000 Editions scientifiq ues et medicales Elsevier SAS.