Despite a century of often successful prevention and control efforts, infec
tious diseases remain an important global problem in public health, causing
over 13 million deaths each year. Changes in society, technology and the m
icroorganisms themselves are contributing to the emergence of new diseases,
the re-emergence of diseases once controlled, and to the development of an
timicrobial resistance. Two areas of special concern in the twenty-first ce
ntury are food-borne disease and antimicrobial resistance. The effective co
ntrol of infectious diseases in the new millennium will require effective p
ublic health infrastructures that will rapidly recognize and respond to the
m and will prevent emerging problems.